Peripheral neuropathy is caused by damage to neurons in the peripheral nervous system, particularly in extremities such as the hands and feet. This damage usually manifests as a painful tingling sensation, which can either occur in multiple areas or can affect only a single neuron. Neuropathy is caused by many things, including chemical exposure, infectious diseases, or chronic diseases such as diabetes (in fact, 60 to 70% of people with diabetes have some sort of nerve damage). Read more here.